ea0021p136 | Diabetes and metabolism | SFEBES2009
Leavy Emma
, Gardiner James
, Buckley Niki
, Richardson Errol
, Martin Niamh
, Bloom Stephen
, Smith Kirsty
The hypothalamus regulates multiple homeostatic systems, and is essential for the regulation of appetite and energy balance. Neuropeptide Y, a 36 amino acid peptide and member of the PP-fold family, is a key hypothalamic neuropeptide involved in the regulation of energy balance, potently stimulating food intake following central administration. NPY is expressed in the arcuate nucleus (ARC) and NPYergic neurones project to multiple hypothalamic nuclei and extra-hypothalamic sit...